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Pathophysiology

Syllabus:

Unit 1

Basic principles of Cell injury and Adaptation: Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury, Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis & Alkalosis, Electrolyte imbalance

Basic mechanism involved in the process of inflammation and repair: Introduction, Clinical signs of inflammation, Different types of Inflammation, Mechanism of Inflammation – Alteration in vascular permeability and blood flow, migration of WBC’s, Mediators of inflammation, Basic principles of wound healing in the skin, Pathophysiology of Atherosclerosis

Unit 2

Cardiovascular System: Hypertension, congestive heart failure, ischemic heart disease (angina, myocardial infarction, atherosclerosis and arteriosclerosis)

Respiratory system: Asthma, Chronic obstructive airways diseases.

Renal system: Acute and chronic renal failure

Unit 3

Haematological Diseases: Iron deficiency, megaloblastic anemia (Vit B12 and folic acid), sickle cell anemia, thalasemia, hereditary acquired anemia, hemophilia

Endocrine system: Diabetes, thyroid diseases, disorders of sex hormones

Nervous system: Epilepsy, Parkinson’s disease, stroke, psychiatric disorders: depression, schizophrenia and Alzheimer’s disease.

Gastrointestinal system: Peptic Ulcer

Unit 4

Inflammatory bowel diseases, jaundice, hepatitis (A,B,C,D,E,F) alcoholic liver disease.

Disease of bones and joints: Rheumatoid arthritis, osteoporosis and gout

Principles of cancer: classification, etiology and pathogenesis of cancer

Diseases of bones and joints: Rheumatoid Arthritis, Osteoporosis, Gout

Unit 5

Infectious diseases: Meningitis, Typhoid, Leprosy, Tuberculosis Urinary tract infections

Sexually transmitted diseases: AIDS, Syphilis, Gonorrhea Recommended Books (Latest Editions)

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